A novel catalytic asymmetric route towards skipped dienes with a methyl-substituted central stereogenic carbon.
نویسندگان
چکیده
A highly efficient method for the enantioselective synthesis of 1,4-dienes (skipped dienes) with a methyl-substituted central stereogenic carbon using copper-catalysed asymmetric allylic alkylation of diene bromides was developed. Excellent regio- and enantioselectivity (up to 97 : 3 SN2'/SN2 ratio and 99% ee) were achieved with broad substrate scope.
منابع مشابه
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عنوان ژورنال:
- Chemical communications
دوره 49 32 شماره
صفحات -
تاریخ انتشار 2013